Il-2 receptor signaling review
Distinct IL2 Receptor Signaling Pattern in Laurence A. Turka Thompson, Matthew A. Burchill, Michael A. Farrar and Rapid Reviews! 30 days from submission to initial decision Negative regulation of phosphatidylinositol 3kinase signaling and IL2mediated proliferation of CD4 CD25 T cellsInterleukin2 (IL2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15, 5 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. il-2 receptor signaling review
Nov 30, 2007 IL2R Signaling and Tregs. The IL2 receptorsignaling complex is composed of three distinct subunits, the chain (CD25), chain (CD122), and chain (CD132) each of which have unique roles in facilitating IL2dependent signal transduction.
Such studies established that IL2 sometimes contributes to optimal primary immune responses, but it is not mandatory. Also discussed are implications of this new appreciation concerning the immunobiology of IL2 with respect to targeting IL2 or its receptor in immunot 0. Institutional Login First published online as a Review in IL2 activation and signaling pathway. Interleukin2 ( IL2) is a TCellderived cytokine important in the regulation of growth and differentiation of TCells, BCells, natural killer cells, glioma cells, and cells of the monocyte lineage. IL2 signaling is mediated by a multichain IL2 receptor complex consisting of an alpha ( IL2R alpha chain), beta ( IL2R beta chain) and gamma ( IL2Ril-2 receptor signaling review IL2 receptor (IL2R or CD25 (NK) and lymphokineactivated killer cells, which mediate signaling and receptor internalization. The 55kDa IL2 (p55, Tac, or CD25) subunit, on the other hand, is expressed by most T, B, and NK cells only after they have been activated by interaction with an antigen or with IL2. IL2 receptors can be